Natural extracts and biomolecules purification
The purification of biomolecules, as well as natural extracts, requires a high degree of technical expertise and state-of-the-art technologies to deliver a robust and effective process leading to a high-purity product.
Whether you’re struggling to purify your molecules, or do not have the capabilities to do so, Axplora can help you!
As a leading contract manufacturer for more than 30 years, we offer best-in-class purification services for molecules used as active ingredients for pharmaceutical or cosmetic products, whether of natural or synthetic origin, for your development, clinical and commercial needs.
A technical expertise in the purification of biomolecules and natural extracts
Recognized to bring the best to purification using key technologies, Axplora is a world leader in the large-scale purification of biomass of animal, plant, microbial, and cell culture origin, including small molecules, lipids, peptides, and proteins. Thanks to our long-standing experience, we are well-placed to address the challenges involved in the purification of your biomolecule or natural extracts:
- Recognized technical expertise
- More than 20 years’ experience in cGMP manufacturing of natural extracts and biomolecules
- More than 100 projects developed and transferred successfully to manufacturing
- Outstanding regulatory and quality assurance track-record
- All manufacturing sites successfully inspected by the FDA and European authorities
- More than 10 API manufacturing processes validated
- Wide range of purification solutions
- Manufacturing of APIs, whatever the source and the molecule type, using a wide range of purification technologies
- Expertise in combining appropriate downstream processing steps, including High- & Low-Pressure chromatography
- Agile and responsive team
- Skilled team of experts reactive to changes in customer needs and biomass variabilities
- 2 development centers and 4 manufacturing sites
- Use of state-of-the-art-equipment
- New cGMP production line commissioned in 2023 (Axplora Pompey site)
Know-how to purify a wide range of biomolecules
We can develop exclusive purification processes whatever the biomolecule type you work on:
- Blood derivative
- Enzyme
- Insulin
- Lipid
- Macrolide antibiotic
- Oligonucleotide
- Omega-3
- Peptide
- Recombinant peptide
- Synthetic peptide
- Plant-based extracts
- Alkaloids
- CBD
- Flavones
- Glycoside
- Saponins
- Taxanes…
- Polysaccharide
- Protein
- Natural protein
- Recombinant Protein
- Rapalog
Our solutions for your biomolecules purification
Axplora offers a full and flexible range of manufacturing services to develop and purify your biomolecules, from process development and analytical support to cGMP manufacturing.
- Process development
- Feasibility studies & development
- Analytical transfer
- Process transfer & optimization
- DoE (Design of Experiments)
- Scale-up
- Proof of Concept (PoC)
- cGMP & non-GMP manufacturing
- Manufacturing
- cGMP and non-GMP manufacturing for clinical & commercial supply from grams to tons
- Process validation
- Analytical support
- Stability studies
Our center of excellence for the purification of your biomolecule
Our purpose-built manufacturing facility is located in Pompey, an hour and a half by high-speed train, east of Paris, France.
Axplora has recently opened a new manufacturing line in Pompey. It features a flexible cGMP set up including a clean room able to accommodate key technologies: extraction, filtration, low, medium, and high-pressure chromatography, Tangential Flow Filtrations, or freeze drying for the purification of biologics and natural extract APIs.
Discover our CDMO services and technologies for APIs:
