Home / Novasep CDMO / Technologies / Small Molecules Purification
Small molecules purification
Get consistent, high‑purity APIs at industrial scale. Our world‑class preparative chromatography systems deliver more than 1,000 tons each year with proven reliability.
Pioneers in purification at scale
Achieve target purity without compromising yield. Novasep CDMO operates the world’s largest chromatography platform, with >30 cGMP systems across our network. We combine >30 years of expertise with continuous manufacturing technologies (Simulated Moving Bed (SMB)) to deliver high-quality, cost-effective outcomes for your most complex small molecules.
Why partner with us?
- 1000s cGMP batches delivered
- 99.5% OTIF performance
- 99.8 compliant batches
- >30 systems installed across 4 sites
- >30 years of leadership in industrial chromatography
- >20 API manufacturing processes validated using chromatography
Purity you can trust
We deliver high-yield results where standard purification fails. By leveraging our Preparative Chromatography and SMB technologies, we separate complex mixtures efficiently, setting industry standards for reliability and sustainability.
Explore related technologies
See how our wider technologies support complex molecules.
Natural Extracts and Biomolecules Purification
Latest updates
Webinar recording
Rethinking Industrial Chiral Manufacturing: Why Chromatography Deserves a Second Look
Overview: The manufacture of chiral active pharmaceutical ingredients (APIs) remains one of the most important challenges in modern pharmaceutical process development, estimations suggest that at least 60% of new APIs are single enantiomer drugs for the last 10 years. While asymmetric synthesis, biocatalysis and diastereoselective crystallisation are well accepted procedures for producing chiral APIs, preparative […]
Whitepaper
Dare to use preparative chromatography at industrial scale for your API
Maximise purity, efficiency, and sustainability. Is purification stalling your API journey to market?You’re not alone! Every molecule is a new frontier—with its own complex terrain. But here’s the bold truth: the future belongs to those who dare to imagine better solutions. Preparative chromatography as a powerful purification technology can unlock major benefits for your complex […]
Case study
Case study – Chromatography
Purification of a complex API using a batch chromatography process Axplora is a pioneer and market leader in preparative chromatography with more than 30’ years track record in chromatography equipment design and commercial manufacturing. We produce 1000’s tons API and more than 3000 batches with industrial chromatography. A major pharmaceutical company tasked the Axplora Pompey […]
Get in touch
Work with the pioneers in purification. Discuss your project with a team managing >30 industrial systems.