Know How

Chemical Reactions

We offer a broad variety of chemical transformations to address synthetic challenges from lab to multi-ton scale:

  • Acetylation / Acid chlorination / Acylation / Alcoholysis / Alkoxylation / Alkylation / Amides synthesis / Amines synthesis / Aromatization
  • Benzoylation
  • Condensation
  • Dealkylation / Debenzylation / Dehalogenation / Dehydratation / Dehydrogenation / Demethylation
  • Epoxydation / Esterification / Ethers synthesis
  • Halogenation / Hydrogenation / Hydrolysis / Hydroxylation
  • Mesylation
  • Oxidation / Oxidation with enzymes / Oxime preparation / Optical resolutions
  • Peroxydation
  • Reduction with enzymes / Reductions with iodides

We have the capabilities to run chemical reactions in broad temperatures ranging from -90 °C to 200 °C, with the ability to isolate starting materials and intermediates from natural sources. Other capabilities include chromatography on silica and ion exchange chromatography.

Particle Design & Micronization

With our vast expertise in customizing particle sizes and extensive crystallization know-how, we produce a wide range of different API grades. For each project, we can offer polymorphic screening to uncover possible new polymorphs and to safeguard polymorphic process stability during scale-up and production. Farmabios has hammer and jet mills on site, allowing milling of the drug substance to the desired particle size distribution.

Continuous improvement

Our teams continuously review process performance after transfer to production in order to identify process improvement opportunities. These improvements allow us to stay ahead of the evolving needs of compendial/quality requirements, commercial/cost improvements and capacity gain needs.

Sterilization by filtration

We can sterilize our products by filtration for parental applications. The manufacturing process takes place in several steps in a closed cycle system. After dissolution in a class 100.000 (C) area, the filtration is performed through a series of cartridges. The following steps (crystallization, drying, micronization, packing) are performed in class 100 (A/B) areas. Compared to the use of classical gamma radiation this generates a lower energy consumption and a more environmental-friendly processing.

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