Natural extracts and biomolecules purification
Purifying biomolecules and natural extracts require a high degree of technical expertise and state-of-the-art technologies to deliver a robust and effective process that leads to a high-purity product.
Whether you’re struggling to purify your molecules or lack the capabilities to do so, Axplora can help you!
As a leading contract manufacturer for more than 30 years, we offer best-in-class purification services for molecules used as active ingredients for pharmaceutical or cosmetic products, whether of natural or synthetic origin, for your development, clinical and commercial needs.
Technical expertise in the purification of biomolecules and natural extracts
Axplora is a world leader in the large-scale purification of biomass of animal, plant, microbial, and cell culture origin, including small molecules, lipids, peptides, and proteins. With our long-standing experience, we are well-placed to address the challenges involved in the purification of your biomolecule or natural extracts:
- Recognized technical expertise
- More than 20 years of experience in cGMP manufacturing of natural extracts and biomolecules
- More than 100 projects developed and transferred successfully to manufacturing
- Outstanding regulatory and quality assurance track-record
- All manufacturing sites successfully inspected by the FDA and European authorities
- More than 10 API manufacturing processes validated
- Wide range of purification solutions
- Manufacturing of APIs, whatever the source and the molecule type, using a wide range of purification technologies
- Expertise in combining appropriate downstream processing steps, including High- & Low-Pressure chromatography
- Agile and responsive team
- A skilled team of experts reactive to changes in customer needs and biomass variabilities
- Two development centers and four manufacturing sites
- Use of state-of-the-art-equipment
- New cGMP production line commissioned in 2023 (Axplora Pompey site)
The know-how to purify a wide range of biomolecules
We can develop exclusive purification processes whatever the biomolecule type you work on:
- Blood derivative
- Enzyme
- Insulin
- Lipid
- Macrolide antibiotic
- Oligonucleotide
- Omega-3
- Peptide
- Recombinant peptide
- Synthetic peptide
- Plant-based extracts
- Alkaloids
- CBD
- Flavones
- Glycoside
- Saponins
- Taxanes…
- Polysaccharide
- Protein
- Natural protein
- Recombinant Protein
- Rapalog
Our solutions for biomolecules purification
Axplora offers a full and flexible range of manufacturing services to develop and purify your biomolecules, from process development and analytical support to cGMP manufacturing.
- Process development
- Feasibility studies & development
- Analytical transfer
- Process transfer & optimization
- DoE (Design of Experiments)
- Scale-up
- Proof of Concept (PoC)
- cGMP & non-GMP manufacturing
- Manufacturing
- cGMP and non-GMP manufacturing for clinical & commercial supply from grams to tons
- Process validation
- Analytical support
- Stability studies
Our center of excellence for the purification of biomolecules
Our purpose-built manufacturing facility is located in Pompey, an hour and a half by high-speed train, east of Paris, France.
Axplora recently opened a new manufacturing line in Pompey. It features a flexible cGMP setup, including a clean room, to accommodate key technologies: extraction, filtration, low, medium, and high-pressure chromatography, Tangential Flow Filtrations, or freeze drying for the purification of biologics and natural extract APIs.
Discover our CDMO services and technologies for APIs:
