From Complexity to Capacity, we’re up for the challenge

Chemical Reactions

We know the challenges that come with an API scale-up. Our experts specialize in challenging chemical transformations with the know-how to address synthetic challenges from a lab to a multi-tonne scale.

  • Acetylation / Acid chlorination / Acylation / Alcoholysis / Alkoxylation / Alkylation / Amides synthesis / Amines synthesis
  • Benzoylation
  • Biocatalysis using enzymes
  • Condensation
  • Debenzylation / Dehalogenation / Dehydratation / Diazotation
  • Epoxydation / Esterification / Ethers synthesis
  • Electrochemistry
  • Halogenation / Hydrogenation / Hydrolysis / Hydroxylation
  • Mesylation
  • Oxidation / Optical resolutions
  • Reductions with iodides

PharmaZell has the capabilities to run chemical reactions in broad temperatures ranging from -50 °C to 240 °C, with the ability to isolate starting materials and intermediates from natural sources. With our internal know-how and broad network of external specialists in distinctive fields, e.g. like enzymatic conversions and electrochemistry, we can address challenging chemistry in research, development, scale-up and production.

Particle Design

With our vast expertise in customizing particle sizes and extensive crystallization know-how, we produce a wide range of different API grades. For each project, we can offer polymorphic screening to uncover possible new polymorphs and to safeguard polymorphic process stability during scale-up and production. Each manufacturing site has hammer and jet mills on site, allowing milling of the drug substance to the desired particle size distribution.

Continuous Improvement

Our teams continuously review process performance after transfer to production in order to identify process improvement opportunities. These improvements allow us to stay ahead of the evolving needs of compendial/quality requirements, commercial/cost improvements and capacity gain needs.

Engage our experts

PharmaZell experts are here to discuss your needs and find solutions. Just click below.